Gastrointestinal stromal tumors (GIST)
- 1 Summary
- 2 Basics
- 2.2 Epidemiology
- 2.3 Pathogenesis
- 2.4 Risk factors
- 4.1 Symptoms
- 5.2 Diagnostics
- 5.3 Classification
- 5.3.2 Stages and staging
- 6 Therapy
- 6.2.2 Surgical treatment
- 6.2.2.1 Primary tumor surgery
- 6.2.2.2 Surgery of metastases
- 6.2.3 Radiotherapy
- 6.2.4 Systemic drug treatment
- 6.2.4.2 Adjuvant therapy (with imatinib)
- 6.2.4.5 Metastatic GIST
- 6.2.4.5.1 First-line therapy with imatinib
- 6.2.4.5.2 Duration of therapy with imatinib
- 6.2.4.5.3 Imatinib resistance
- 6.2.4.5.4 PDGFRA-D842V mutation
- 6.2.4.5.5 Second-line therapy with sunitinib
- 6.2.4.5.6 Third-line therapy with regorafenib
- 6.2.4.5.7 Fourth-line therapy with ripretinib
- 6.2.6 Substances
- 6.2.6.1 Imatinib
- 6.2.6.2 Sunitinib
- 6.2.6.3 Regorafenib
- 6.2.6.4 Ripretinib
- 6.2.6.5 Avapritinib
- Supplementary Information
-
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Gastrointestinal stromal tumors (GIST)
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1Summary
Gastrointestinal stromal tumors (GIST) are of mesenchymal origin and belong to the rare malignant tumors. Men and women are affected with approximately equal frequency, and the median age of onset is 65-70 years. The most common primary sites are in the stomach and small intestine.
In resectable GIST, treatment is multimodal. For tumors with a high risk of recurrence, as determined by tumor size and mitotic rate, adjuvant therapy with imatinib is indicated.
In metastatic disease, systemic drug therapy is the treatment of choice. For imatinib-sensitive tumors, imatinib is available as first-line therapy, sunitinib as second-line therapy, and regorafenib as third-line therapy. Ripretinib, a new standard of care for fourth-line therapy, is available since 2021. Avapritinib is the therapy of choice if a PDGFRA mutation exon 18 D842V is detected.
The determination of the KIT or PDGFRA mutation status is an obligatory part of the initial diagnosis of GIST for which systemic treatment is indicated. Approximately 80-85% of all GIST have a mutation in the KIT gene, and approximately 10-15% have a mutation in the PDGF receptor-alpha gene (PDGFRA), both of which are considered to be predominantly imatinib-sensitive. Tumors with a c-KIT/PDGFR-A wild-type status or PDGFRA p.D842V mutations are considered imatinib-resistant.
2Basics
2.1Definition and basic information
Gastrointestinal stromal tumors (GIST) represent the most common mesenchymal tumors of the gastrointestinal tract and account for approximately 20-25% of all sarcomas. Their incidence is approximately 10-15 / 106 population and year. The median age at diagnosis is approximately 65-70 years (range: 16-94 years), and the sex distribution is almost equal.
The vast majority of GIST occur sporadically. Most frequent localizations are stomach (50-60%) and small intestine (20-30%); less frequently GIST occur in the colorectum (5-10%) and esophagus (≤ 1%), for Germany see also Figure 4. The occurrence of extraintestinal GIST (E-GIST) is now increasingly in doubt, as more likely metastases of an undetected primary in the gastrointestinal tract are considered [1].
2.2Epidemiology
The results presented here are based on data from population-based cancer registries in Germany. GIST were recorded using histology codes 8936/1 (gastrointestinal stromal tumor o.n.A.) and 8936/3 (gastrointestinal stromal sarcoma). Registries with a continuously high estimated completeness (>90%) for malignant tumors of the digestive organs in the studied period of 2003 to 2018 were selected. These registries cover approximately 36% of the German population. The disease rates thus determined were extrapolated to the population of Germany to estimate current nationwide case rates. Age- and sex-specific disease rates and the distribution of cases among the different localizations of the digestive tract were evaluated for the period 2016-2018. Relative survival rates, which take into account survival in the age-matched general population and can be considered a measure of disease-specific survival, were calculated using the period approach for the period 2014-2018. The epidemiology of GIST is not part of the standard evaluations of cancer registries; therefore, no area-wide figures are available for Austria and Switzerland. Results from the Dutch cancer registry were used as comparative values for incidence [54].
When assessing incidence trends and the temporal development of disease numbers, it should be noted that GIST were not recorded via histology with independent coding until the introduction of ICD-03 (from around 2003).
The age-standardized disease rates (per 100,000 persons, old European standard) more than doubled in Germany from 2003 to 2011, after which no further significant increase was observed. The course and level of the disease rates are largely consistent with the results from the Netherlands (Figure 1). The progression suggests that the initial increase in incidence is due to improvements in documentation and coding rather than an actual increase in the risk of disease.
The mean (median) age of onset in Germany is currently 71 years for women and 70 years for men; only 8% of those affected are younger than 50 years at diagnosis. The age-specific incidence rates increase continuously with age in both sexes until the 8th decade of life and then decline again gradually (Figure 2). Men have a slightly higher risk of disease than women of the same age, which is compensated by the higher proportion of women in the older age groups: extrapolated, 970 women and 949 men were diagnosed with GIST per year in Germany in recent years. About two-thirds of cases involve the stomach, about one-quarter the small intestine, and just under 4% the colon or rectum (Figure 3). Differences in the distribution of localization between the sexes are not observed.
The 5-year relative survival rate for 2014-2018 is 82.7% (95% confidence interval: 79.5%-85.9%) for women (83.9%), slightly higher than for men (81.3%). For GIST of the stomach, the rate is higher at 87% compared with small bowel (81%), colorectum (75%), or other sites (57%) (Figure 4). For the Dutch Cancer Registry, an overall 5-year relative survival of 81% is currently reported for GIST [53, 54].
2.3Pathogenesis
The histogenetic origin of GIST is considered to be the interstitial cells of Cajal (ICC) or corresponding progenitor cells. ICC are involved as "pacemaker cells" in the control of gastric/intestinal motility and express KIT (CD117) protein. Macroscopically, larger GIST in particular may show cystic areas and hemorrhage. Histopathologically, GIST usually present as spindle cell (60-70%), epithelioid (20-30%) or mixed tumors. The leading immunohistochemical feature of GIST is the expression of KIT [CD117] and DOG-1, which can be detected in approximately 95% of all GIST. DOG-1 is also mostly expressed in KIT-negative GIST [1, 9].
A mutation of the KIT gene is found in about 80-85% of all GIST. The exon 11 coding for the transmembrane domain (approx. 70%) and the exon 9 coding for the extracellular domain (approx. 10-15%) are most frequently affected. The kinase I (exon 13) or the activation domain (exon 17) are rarely affected by primary mutations, with approximately 1% each [10]. In addition, an activating, imatinib-sensitive mutation in KIT exon 8 (p.D419del) occurs very rarely (<1%) and was first described as a germline mutation in a family with GIST and mastocytosis [11], but may also occur sporadically.
In approximately 10-15% of all GIST, a mutation is found in the PDGF receptor alpha gene (PDGFRA), either in exon 12 encoding the juxtamembrane domain, exon 14 encoding the tyrosine kinase 1 domain, or exon 18 encoding the activation domain.
In the remaining approximately 10% of all GIST, no mutation of the KIT or PDGFRA gene can be detected, which is why these tumors have been simplistically referred to as "wild-type GIST" [10]. However, the term "wild-type GIST" is increasingly criticized because other rare mutations have now been found, for example, in BRAF [12], NF1, the succinate dehydrogenase (SDH) genes, and the RAS genes, which represent alternative pathomechanisms. The term "quadruple-negative (q-wt) GIST" (non-KIT, non-PDGFRA, non-RAS, non-SDH) describes the phenomenon that none of the known activating mutations can be detected.
A hereditary predisposition is observed only very rarely. These are either familial GIST with corresponding germline mutation of the KIT or PDGFRA gene, GIST in the context of Carney-Stratakis syndrome (with SDH mutations), or GIST associated with neurofibromatosis type-1 (NF-1; von Recklinghausen disease) (see Table 1) [13].
GIST occur very rarely in children/adolescents (1-2%); mostly girls are affected. In these pediatric GIST, which usually occur multifocally, mutations of the KIT or PDGFRA gene are found only exceptionally; IGF-1 receptor amplification/overexpression can often be detected.
2.4Risk factors
Risk factors for the development of GIST are not known to date.
3Prevention and early detection
There is no evidence of effective measures for prevention or early detection of GIST in terms of a screening program.
4Clinical image
4.1Symptoms
Most frequent localizations of sporadic GIST are stomach (50-60%) and small intestine (20-30%); rarer localizations are rectum (5-10%), esophagus (≤1%) and mesentery/omentum (2-5%). The occurrence of extra-gastrointestinal GIST (E-GIST) has also been described but is now increasingly in doubt; metastases from an undetected primary to the gastrointestinal tract are considered more likely [8, 14].
Sporadic GIST almost always manifest as solitary tumors, whereas GIST in the context of rare familial genesis and NF-1 usually present as multifocal tumors in the stomach (q-wt, SDH deficiency) or small intestine (NF-1). In addition, sporadic GIST rarely occur at multiple sites synchronously or metachronously [15].
The clinical symptoms leading to the diagnosis are usually nonspecific (e.g., feeling of fullness, abdominal discomfort, increase in abdominal circumference). In up to 30% of patients, GIST is diagnosed incidentally during endoscopic examinations or surgery for other indications. 10% of patients are diagnosed as emergencies (6.4% small bowel mostly as obstruction, 3.2% stomach/duodenum as gastrointestinal bleeding [55].
At diagnosis, metastasis is detectable in 20-50% of patients. The liver and peritoneum/omentum are most commonly involved. Extra-abdominal metastases are rare at <10% but are found in advanced, refractory GIST in up to 20-25%. Lymph node metastases, with the exception of syndromal GIST, are so rare, as in the majority of other sarcomas, that they are usually of no clinical and thus surgical significance [1].
4.2Incidental findings
In up to 25% of affected patients, the diagnosis of GIST is made incidentally during the increasing use of imaging such as endoscopy or during surgery for other reasons [1].
To be differentiated from these are the so-called micro-GISTs (GISTs with a diameter of less than 1 cm), which are also frequently found incidentally. Data from Japanese and German studies indicate that these occur primarily in the gastroesophageal junction and proximal stomach, and are seen much less frequently elsewhere in the gastrointestinal tract. These lesions typically have no or very few mitoses and are therefore usually not clinically relevant [16, 17].
5Diagnosis
5.1Diagnostic criteria
5.2Diagnostics
In addition to endoscopic or endosonographic diagnostics, computed tomography (CT) is of greatest importance for the diagnosis of spread, restaging/post-treatment control and follow-up. Positron emission tomography (PET) imaging may be helpful in individual cases to assess early response to drug therapy or to differentiate between benign and malignant changes [1, 9]. Response to therapy by CT can be determined according to the so-called Choi criteria. A size reduction of >10% and/or a density reduction (HU) of ≥ 15% are considered as response to therapy [18].
If necessary, biopsy can be performed by endoscopy or endosonography if this is technically feasible without risking intraabdominal dissemination of tumor cells [19]. GIST are usually fragile and highly vascularized tumors that originate from the muscularis propria and are therefore often difficult to access endoscopically. Evaluation of the SSG-AIO-XVIII study showed that transabdominal biopsy did not result in a worsened prognosis [20]. Percutaneous tumor biopsy should be considered especially when other tumors, e.g., lymphoma, are considered for differential diagnosis or when neoadjuvant therapy is indicated due to tumor size or spread [21].
Molecular genetic testing to determine KIT or PDGFRA mutation status is now an obligatory part of initial diagnosis in GIST for which drug therapy is indicated [22].
An overview of the diagnostic procedures is given in Table 2.
5.3Classification
The current TNM classification [21] divides GIST localizations into the following anatomic districts and subdistricts (ICD 10):
Esophagus (C15)
Stomach (C16)
Small intestine (C17)
Duodenum (C17.0)
Jejunum (C17.1)
Ileum (C17.2)
Colon (C18)
Rectum (C20)
Omentum (C48.1)
Mesentery (C48.1)
The regional lymph nodes correspond to the respective localization of the primary tumor but, as mentioned above, do not play a biological role in most GIST.
Grading is based on the mitotic count:
Low mitotic count: 5 or less per 5 mm².
High mitosis number: over 5 per 5 mm²
5.3.1Not applicable (subtypes)
5.3.2Stages and staging
Classification of the extent of the primary tumor and metastasis is based on the UICC/AJCC TNM criteria. Since January 1, 2017, the 8th edition has been used in Europe [23]. The TNM criteria are summarized in Table 3, and the staging is summarized in Table 4 and Table 5.
Classification | Tumor | |
|---|---|---|
T | Primary tumor | |
| T1 | Tumor ≤ 2 cm in largest extension |
| T2 | Tumor 2-5 cm in largest extension |
| T3 | Tumor > 5 cm but ≤ 10 cm in largest extension |
| T4 | Tumor > 10 cm in largest extension |
N | Regional lymph nodes | |
| Nx | Regional lymph nodes cannot be assessed |
| N0 | No regional lymph node metastases |
| N1 | Regional lymph node metastases |
M | Distant metastases | |
| M0 | No distant metastases |
| M1 | Distant metastases |
Regional lymph nodes are rare in GIST. Cases in which lymph node status is not determined clinically or pathologically may be classified as N0 rather than Nx of pNX. However, the usefulness of such a classification is questionable.
Stage | T | N | M | Mitotic rate |
|---|---|---|---|---|
Ia | T1, T2 | N0 | M0 | low |
Ib | T3 | N0 | M0 | low |
II | T1, T2 | N0 | M0 | high |
T4 | N0 | M0 | low | |
IIIa | T3 | N0 | M0 | high |
IIIb | T4 | N0 | M0 | high |
IV | Each T | N1 | M0 | any |
Each T | Any N | M1 | any |
The criteria for the stages of gastric GIST can be applied to primary solitary GIST of the omentum, although there is no established evidence for this.
Stage | T | N | M | Mitotic rate |
|---|---|---|---|---|
I | T1, T2 | N0 | M0 | low |
II | T3 | N0 | M0 | low |
IIIa | T1 | N0 | M0 | high |
T4 | N0 | M0 | low | |
IIIb | T2, T3, T4 | N0 | M0 | high |
IV | Each T | N1 | M0 | any |
Each T | Any N | M1 | any |
The criteria for the stages of small bowel GIST can be applied to GIST in rarer locations such as the esophagus, colon, rectum, and mesentery.
5.4Prognostic factors
Clinically significant prognostic factors include mitotic rate, tumor size, and primary tumor location. To estimate the probability of metastasis, different risk categories are distinguished, which are summarized in Table 6. Here, however, it is not possible to completely exclude the risk of metastasis on the basis of the prognostic parameters mentioned. The 5-year overall survival rate of patients with surgically resected primary tumor in the era before the introduction of imatinib has been about 50%, and in patients with tumor size > 10 cm it was 20-35%. The median survival of patients with metastatic disease is currently approximately 60 months, and the 5-year survival rate is approximately 45%.
It remains problematic that in the previous risk classifications the number of mitoses is applied dichotomized, (e.g., < or ≥ 5 mitoses), which does not completely represent the biological reality. Joensuu's classification uses so-called contour maps, where tumor size and mitotic count are applied as continuous variables [24]. This classification is nowadays considered to be the closest to clinical needs, however, the classification of Miettinen and Lasota from 2006 is still more commonly used [25]. There is general agreement that mitoses are counted in 5 mm² instead of 50 HPF (which currently corresponds to about 18 to 20 HPF on modern microscopes) [22].
KIT genotype represents both a prognostic and a predictive parameter. Thus, patients with a KIT exon 11 deletion have a higher risk of recurrence than those with exon 11 insertion or point mutation, PDGFRA mutation or wild type [26]. The prognostic relevance of KIT exon 9 mutations is controversial because they occur almost exclusively outside the stomach and the biology of intestinal GIST is mostly more aggressive than that of gastric GIST.
Patients who experience intraperitoneal tumor hemorrhage, rupture, or injury almost always develop peritoneal metastases [27].
| Risk of progression/recurrence | ||||||||
|---|---|---|---|---|---|---|---|---|---|
Mitosis number | Size (cm) | Stomach | % | Duodenum | % | Small intestine | % | Rectum | % |
≤ 5 per 5 mm²* | ≤ 2 | no risk | 0 | no risk | 0 | no risk | 0 | no risk | 0 |
>2 ≤ 5 | very low | low | low | low | |||||
> 5 ≤ 10 | low | high | 34 | moderate | 24 | high | 57 | ||
| > 10 | moderate | 12 | high | high | 52 | high | ||
> 5 per 5 mm²* | ≤ 2 | no risk** | 0** | N/A (high) | n.a. | high | 50 | high | 54 |
>2 ≤ 5 | moderate | 16 | high | 50 | high | 73 | high | 52 | |
> 5 ≤ 10 | high | 55 | high | 86 | high | 85 | high | 71 | |
| > 10 | high | 86 | high | high | 90 | high | ||
*the currently common counting of mitoses is in "5 mm" (corresponds to about 18-20 HPF depending on the microscope), in the original publication it was 50 HPF with, however, much older microscopes with smaller fields of view, which is why the area measure applies today;
**very small numbers of cases.
6Therapy
6.1Treatment structure
An optimal treatment strategy for gastrointestinal stromal tumors requires the cooperation of the different specialties already at diagnosis. It has two goals: locoregional tumor control and prevention/therapy of distant metastasis. The treatment strategy is determined by tumor stage, prognostic factors such as histology, mitotic rate, size and location, and patient-specific factors.
The treatment algorithm is shown in Figure 5.
6.2Treatment modalities
6.2.1Therapy-free monitoring („watch & wait”)
Small GIST of the stomach (< 2 cm) are - after resection - associated with a very low recurrence rate, so that in individual cases (e.g., age, comorbidities, perioperative risks), after discussion with the patient, they can initially also be progress-controlled, provided that the size does not exceed 2 cm and no significant tumor growth is detected during endoscopic/endosonographic controls (initially 3-6 monthly). Small GIST of other locations (especially rectal) have a significantly higher risk of progression/metastasis and should be treated surgically as a rule.
6.2.2Surgical treatment
6.2.2.1Primary tumor surgery
If the primary tumor appears initially resectable, primary resection is indicated. In gastric GIST, this is usually performed as a wedge resection, if technically possible with a safety margin of 1-2 cm. If necessary, a segmental resection (small/ large bowel) or an 'en bloc' resection is performed. For esophageal GIST smaller than 3 cm, enucleation may also be sufficient to perform a low-morbidity tumor removal [56]. Lymphadenectomy is not regularly required due to the rarity of lymph node metastases. If primary R0 resection does not appear possible or requires mutilating surgery, preoperative (neoadjuvant) therapy with imatinib is indicated (see chapter 6.2.4.1) [19, 21, 56].
6.2.2.2Surgery of metastases
Data from prospective studies on surgical resection of metastases are not available. Some, but not all, retrospective analyses showed a more favorable prognosis of patients who underwent secondary resection, usually after imatinib pretreatment with treatment response. However, it is unclear to date whether the more favorable survival data of operated patients are due to surgical resection or to patient selection. Unfortunately, a prospective study set up to clarify this question had to be discontinued due to poor recruitment [28].
If complete tumor/metastasis resection seems possible and is considered, it should be performed in the phase of therapy response (partial remission or stable disease). Even limited tumor progression under ongoing drug therapy worsens the prognosis; in the case of generalized progression, surgery is not indicated due to the unfavorable prognosis except to control complications. Continuation of drug therapy is mandatory even in case of complete removal of metastases [29].
6.2.2.3Secondary tumor/metastasis resections after imatinib induction chemotherapy
To date, there are no prospective, randomized studies demonstrating that resection of residual unilocular or oligotopic tumor manifestations after imatinib induction therapy is of prognostic benefit. However, retrospective analyses from various institutions suggest that secondary resections are associated with a better prognosis when performed in patients with tumor response (tumor shrinkage or arrest), possibly still in focal progression, and R0 resection can be achieved [30, 31, 32]. In multifocal progression and/or anticipatory R2 resection, elective tumor resection is usually not indicated.
6.2.3Radiotherapy
There are no conclusive data on radiotherapy of GIST. Possible indications for palliative radiotherapy are (rare) bone metastases or irresectable tumors of unfavorable localization (e.g., rectum, esophagus) with refractoriness to drug therapy.
6.2.4Systemic drug treatment
6.2.4.1Neoadjuvant therapy (with imatinib)
If complete tumor resection is not or only questionably possible due to primary tumor size or location, or mutilating surgery appears necessary, preoperative/neoadjuvant therapy with imatinib for achieving tumor shrinkage should be evaluated. For GIST of the stomach, a rate of partial response to imatinib of 75%, a reduction in median tumor diameter of nearly 50%, and an R0 resection rate of 94% can be expected. In a quarter of patients, the residual tumor can also be resected laparoscopically, if necessary, and gastric continuity can be preserved in 96% of patients [57]. Knowledge of the KIT/PDGFRA genotype as a predictive factor for treatment response to imatinib is determining treatment in these cases, which is why mutation analysis should definitely be performed. In the case of a PDGFRA-D842V mutation associated with imatinib resistance, neoadjuvant therapy with avapritinib can be considered according to the current ESMO guidelines [22]. In contrast, if a KIT wild-type tumor is present, neoadjuvant therapy with imatinib is not an option, as no tumor shrinkage can be expected in this case.
Resectability is evaluated at 3-4 monthly intervals during ongoing imatinib therapy. When maximum response is achieved, tumor resection (see above) is followed (usually within 6-12 months).
6.2.4.2Adjuvant therapy (with imatinib)
The value of adjuvant therapy with imatinib was investigated in three randomized trials. First results were obtained in a double-blind, placebo-controlled American phase III study (ACOSOG Z9001) with 713 patients. Patients with a completely excised KIT-positive GIST of at least 3 cm in size were eligible for inclusion, and mitotic count was not considered. The duration of therapy was 1 year. Initial results showed a significant improvement in recurrence-free survival (RFS) with imatinib treatment for 1 year compared with placebo (98% vs. 83%, p <0.0001). The study was stopped early due to its unequivocal outcome. Retrospectively, it was shown that high-risk patients in particular benefited: at 2-year follow-up, relapse-free survival was 77% vs. 41% for high-risk (p <0.0001), 98% vs. 76% for intermediate-risk (p = 0.05), and 98% for low-risk with imatinib and placebo, respectively (p = 0.92). Based on these data, the U.S. authorities approved imatinib for adjuvant treatment for 1 year in December 2008 [33].
Approval for adjuvant therapy with imatinib in Europe by the EMA was granted in April 2009. In contrast to the U.S. label, which does not specify which patients should be treated, the EMA specifies approval for patients "at significant risk of relapse." Patients with a low risk of relapse should not receive adjuvant imatinib treatment.
In the Scandinavian-German study SSGXVIII, a total of 400 patients at high risk of relapse were studied. A treatment duration of 1 year was compared with a duration of 3 years. Results showed a significant improvement in relapse-free survival and overall survival with 36 months of treatment compared to 12 months. In 2020, published data on the 10-year follow-up of the study showed an overall survival in the intention-to-treat population of 65% at 10 years for the group receiving 1 year of therapy and 79% with 3 years of therapy [34]. Based on these results, 3 years of therapy is internationally considered the gold standard for adjuvant therapy in patients at high risk of recurrence.
The third randomized trial is a phase III EORTC intergroup study with 900 patients. Randomization was to a treatment arm with imatinib 400 mg/day for 2 years vs. an observation arm. Patients at intermediate and high risk of relapse according to consensus criteria were included. The primary endpoint was "imatinib failure-free survival," i.e., time to progression with new imatinib treatment after relapse occurred despite or without adjuvant therapy. Here, there was a trend for the group at high risk of relapse, but it did not reach significance. For the secondary endpoint "relapse-free survival", however, the difference was highly significant (p<0.0001) [35].
The question of the optimal duration of treatment has not been conclusively resolved. The currently ongoing SSG XXII trial is investigating in high-risk patients whether two additional years of therapy after 3 years of treatment will result in an advantage over no further therapy. Recruitment has just been completed.
Mutation analysis with regard to a KIT or PDGFRA mutation is an essential component of the therapy decision in the adjuvant situation. On the one hand, the mutation status represents a prognostic factor, on the other hand, not all mutations respond to imatinib. Therefore, the mutation status must be determined in an experienced laboratory before starting adjuvant therapy.
The best dosage of imatinib in adjuvant in patients with a KIT exon 9 mutation remains unresolved. Considering that a higher dosage of 800 mg/day approximately triples the response rate and progression-free survival compared with a dosage of 400 mg/day in patients with metastatic GIST, this would also argue for a higher imatinib dose in the adjuvant setting. According to many experts, patients with an exon 9 mutation benefit from higher dosing, but this has not yet been investigated in randomized trials.
Patients with a D842V mutation in exon 18 of PDGFRA should generally not be treated adjuvantly, regardless of the risk of relapse. This genotype does not respond to imatinib either in vitro or in vivo and is also characterized by a mostly rather indolent course. Patients with other mutations in PDGFRA receive adjuvant therapy according to their risk of relapse.
Wild-type GIST is a heterogeneous subgroup without evidence of an activating mutation in KIT or PDGFRA. In the SSGXVIII trial, with a small number of cases, none of the treatment arms proved superior. If SDH deficiency or an association with neurofibromatosis type 1 is detected, imatinib is not expected to have a beneficial effect. In patients with "wild-type GIST" who do not fall into the typical age group, a complementary reference pathology examination should always be performed to exclude technical errors in molecular pathology.
6.2.4.3Additive imatinib therapy after metastasectomy.
After metastasectomy, tumor progression/recurrence can be expected within a few months in the majority of patients, unless surgery is followed by systemic drug treatment. Therefore, according to current knowledge, imatinib therapy should also be given after metastasectomy. This also applies to patients who received preoperative imatinib therapy and did not show (oligotopic/generalized) tumor progression thereunder. The optimal duration of this therapy is not known. Typically, imatinib therapy is continued until progression is demonstrated.
6.2.4.4Pre- or intraoperatively ruptured GIST
A special situation results from pre- or intraoperative rupture of the GIST. Here, the „universal definition“ of 2019 [70] should be applied. After (true) rupture, a very high recurrence rate must be expected [27], irrespective of adjuvant therapy with imatinib for 3 years [71, 72, 73]. Therefore, international guidelines recommend to treat a ruptured GIST in analogy to a metastatic GIST for an unlimited time period [22, 74].
6.2.4.5Metastatic GIST
Systemic drug treatment is the first-line treatment for advanced GIST, see Figure 6.
1 look for other molecular alterations: BRAF, KRAS, NRAS, SDH, NF1 (see text); in case of SDH-deficiency consider regorafenib
6.2.4.5.1First-line therapy with imatinib
Initial therapy with the tyrosine kinase inhibitor imatinib is the therapy of choice for patients with metastatic GIST [36, 37, 38]. In the first large trials of imatinib, a median overall survival of approximately 52 months was reported for patients with metastatic/irresectable GIST. Depending on the genotype, median survival times of 66 months were observed for tumors with KIT exon 11 mutation, 38 months for those with KIT exon 9 mutation, and 40 months for tumors with KIT/PDGFRA wild-type. The 10-year survival rates are reported as around 20%. Median progression-free survival in the SWOG S0033 trial was 25 months for GIST with KIT exon 11 mutation, 17 months for those with KIT exon 9 mutation, and 13 months for imatinib-treated patients with KIT/PDGFRA wild-type GIST [39].
The rate of objective remissions (according to RECIST) achievable with imatinib is approximately 50-60% and the rate of prognostically equivalent tumor stabilizations is approximately 30%. For patients with KIT exon 11 aberrations, the response rate with imatinib dosing at 400 mg/day is approximately 70-90%. An initial higher imatinib dose does not result in significantly higher response rates or improvement in progression-free survival in this patient group. In contrast, the response rate in patients with KIT exon 9 mutation at 400 mg imatinib/day is only about 20% versus 50-65% at a dose of 800 mg/day. Progression-free survival is also improved in patients with KIT exon 9 mutation by a higher imatinib dose (400 mg: 6 months; 800 mg: 19 months; p=0.017); for overall survival, a risk reduction of 31% for higher-dose imatinib was found, probably not significant due to crossover.
The treatment response of patients with KIT/PDGFRA wild-type has been assessed very divergently in older studies. In the B222 phase II trial, the PR rate was 0% and the SD rate was 33% [40]. In the 'North American Intergroup' study of imatinib, a PR rate of 33% and an SD rate of 28% were reported [41]. Majority of the group of patients with KIT/PDGFRA wild-type GIST are likely to be those with SDH-deficient GIST, and less frequently NF1- or BRAF-mutated tumors. Objective response to imatinib is expected in only 2-8% in SDH-deficient GIST [39], but is likely to be somewhat more favorable for sunitinib and regorafenib.
The recommended dosages are summarized in Table 7.
6.2.4.5.2Duration of therapy with imatinib
The results of the French BFR14 trial [42] showed that discontinuation of imatinib therapy leads to progression after a relatively short interval even after several years of treatment in patients with advanced stable GIST, including those with complete response (CR) or no evidence of disease. After 3 years of therapy, 2-year PFS rates were 16% after discontinuation of imatinib and 80% for continued therapy, respectively. Even after 5 years, the progression/recurrence rate was still 45% after discontinuation of imatinib. Of the patients with CR and partial response, respectively, at the time of imatinib discontinuation, only 41% and 56% achieved CR and PR, respectively, again as the best treatment response after restarting imatinib. Accordingly, therapy should not be interrupted or stopped for a prolonged period of time, if possible, even after several years of treatment.
6.2.4.5.3Imatinib resistance
Primary imatinib resistance is seen in approximately 10% of GIST patients [43]. This is defined by tumor progression in the first 3-6 months of therapy. At this point, at the latest, the expertise of a sarcoma/GIST center should be consulted to verify the histopathological diagnosis and to exclude possible therapy-associated pseudoprogression.
Primary resistance to imatinib is found in PDGFRA mutations (D842V, DI842-843IM, RD841-842KI), in most primary exon 17 mutations, and in rare genotypes with KIT/PDGFRA-independent oncogenic mechanisms (BRAF mutations, NF1, SDH deficiency) [58]. Early progression is also seen, particularly in patients with primary exon 9 mutation, under a standard dose of 400 mg [59]. Patients who have a primary KIT exon 11 mutation are generally always considered to be imatinib-sensitive, and early progressions almost always have pharmacokinetic causes (interactions, absorption, compliance).
In about 40-50% of patients, tumor progression, i.e., secondary imatinib resistance, is observed after an average of 2 years. In about half of the cases, this initially manifests itself in the form of newly appearing, hyperdense "nodules" within existing, mostly hypodense metastases ("nodule in a mass"). Further progression according to conventional criteria is then subsequently observed usually after about 5 months. Secondary mutations are detectable in about 50-80% of cases, mostly affecting the ATP-binding domain (exon 13/14) or the kinase domain (exon 17/18). Secondary KIT mutations are mostly found in tumors with primary exon 11 mutation, less frequently in primary exon 9 mutation. Different secondary mutations in different metastases are typical, and about one-third of cases show two different secondary mutations within one metastasis. Other mechanisms of imatinib resistance include KIT amplifications, loss of the wild-type allele, or mutations leading to KIT-independent constitutive activation of downstream signal transduction pathways (e.g., aberrations of PI3K, PTEN, NF1, TSC1 or 2, NRAS, KRAS) [60].
Pharmacokinetic resistance should also be considered. Examples include reduced binding affinity of imatinib in KIT exon 9 mutant tumors, KIT gene amplification, and comedications (via CYP3A4), which may lead to changes in imatinib plasma levels. Low plasma levels are associated with significantly shorter progression-free times than higher imatinib levels. It is also important to review patient compliance in this context.
If tumor progression is detected during ongoing therapy with imatinib at a dose of 400 mg/day, a dose increase of imatinib to 600-800 mg/day can be considered [44]. However, as the response or 'clinical benefit' rate after dose escalation is only about 7% in patients with exon 11 mutation, this is often not done in clinical practice. However, dose escalation may be useful after extensive gastric resection or gastrectomy, as often only subtherapeutic blood levels of imatinib are achieved. If a dose increase does not lead to renewed tumor stabilization or is not feasible in the longer term due to intolerance, a change in therapy to sunitinib is indicated.
Based on in vitro as well as in vivo data, the different sensitivity of secondary KIT mutations to the various tyrosine kinase inhibitors used in GIST is nowadays well characterized [61]. Nevertheless, considering tumor heterogeneity, a repeat molecular KIT analysis of tumor tissue progressing under imatinib and a therapy choice based on this analysis is not recommended outside of trials. In order to overcome the problem of tumor heterogeneity in the future, intensive research is currently being conducted to establish liquid biopsy diagnostics in GIST [62]. GIST, in contrast to lung and colon carcinomas, unfortunately secrete only very small amounts of ctDNA, mostly only at a very advanced tumor stage. The optimal preanalytical handling of the samples as well as the interpretation of the results must therefore be further investigated on the basis of studies [63] before this technique can be used in clinical practice.
6.2.4.5.4PDGFRA-D842V mutation
Patients whose tumors have a valine substitution in codon 842 (p.D842V) of PDGFRA should be treated with avapritinib in case of non-resectable or metastatic disease.
Avapritinib is a highly potent PDGFRA inhibitor that achieved a remission rate of 91% in 56 patients with D842V mutation and clinical benefit in 98% of patients in the NAVIGATOR trial. Median progression-free survival was 34 months and median overall survival has not been achieved to date [64, 65]. Avapritinib is well tolerated overall with predominantly mild side effects. Of particular concern, however, are neurocognitive side effects, which can occur in more than 50% of cases, especially in elderly patients. Education on these side effects should always include persons from the immediate social environment in order to sensitize them to the multi-layered symptoms (disturbance of memory and movement, psychiatric symptoms, behavioral changes, etc.). Immediate discontinuation of therapy for at least two weeks, even for mild disorders, is mandatory and an important prerequisite to ensure long-term treatment with avapritinib [66]. To date, treatment is without alternative for patients with this genotype and discontinuation due to side effects is prognostically very unfavorable.
Patients with this mutation do not respond to imatinib, sunitinib, regorafenib, and ripretinib, and therefore these agents should not be used. Local treatment modalities may be considered, particularly in cases of focal progression on avapritinib, which may allow prolonged disease control with avapritinib. The median life expectancy after discontinuation of therapy due to progression is only a few weeks [67].
Avapritinib resistance develops by selecting clones with secondary mutations in exon 13, 14, and 15, in analogy to the mechanisms in KIT-mutated GIST. In particular, mutations in the solvent front region (p.G680R) lead to absolute avapritinib resistance, for which no alternative inhibitors are available to date [67].
Patients with the presence of a PDGFRA-D842V mutation should be treated in clinical trials and/or presented at a sarcoma center when possible.
6.2.4.5.5Second-line therapy with sunitinib
Sunitinib is approved for second-line therapy after imatinib failure and for patients with imatinib intolerance [46, 47, 48]. Phase I-III trials have demonstrated its efficacy in imatinib-refractory GIST. A placebo-controlled phase III trial found a tumor stabilization rate of 58% and a remission rate of 7%. Median progression-free survival was 6.8 months with sunitinib versus 1.6 months with placebo. Overall survival was also significantly improved with sunitinib despite the "cross-over" design. Treatment response to sunitinib correlated with KIT mutation status. Thus, progression-free and overall survival are significantly higher in patients with (pre-imatinib) exon 9 mutation and KIT wild-type than with KIT exon 11 mutation (PFS: 19 vs. 5 months; OS: 28 vs. 12 months). Sunitinib may be effective for secondary mutations in the ATP-binding domain (c-KIT exon 13/14), whereas imatinib typically shows no activity here. For secondary mutations in the kinase activation domain (exons 17/18), sunitinib is usually ineffective, so that alternative treatment options should be considered.
The dosage of sunitinib tested and approved in initial studies is 50 mg/day for 28 days, followed by a 14-day break in therapy. In a phase II trial, continuous dosing of 37.5 mg was tested. The median progression-free survival was 34 weeks and overall survival was 107 weeks, making this route of administration an option for patients in whom 50 mg/day for 4 weeks is poorly tolerable.
6.2.4.5.6Third-line therapy with regorafenib
Regorafenib is approved as third-line therapy after failure of imatinib and sunitinib. In the 'GRID' phase III trial, regorafenib was compared to placebo/'best supportive care' with a 'cross-over' to regorafenib upon progression on placebo. Similar to sunitinib, regorafenib is found to have a low rate of objective remission of only 4.5%. Median PFS was 4 months longer than placebo (4.8 vs. 0.9 months); survival benefits were probably not apparent as a result of cross-over. Regorafenib showed efficacy in patients with primary KIT exon 11 or exon 9 mutations, as well as in KIT/PDGFRA wild-type (SDH deficient) GIST and certain secondary KIT exon 17 mutations [49].
The standard dosage is 160 mg/day for 3 weeks, followed by a 1-week break. Similar to sunitinib, regorafenib should be administered in a personalized, toxicity-adapted manner.
6.2.4.5.7Fourth-line therapy with ripretinib
Ripretinib is approved after pretreatment with three therapies, including imatinib. In the INVICTUS trial, ripretinib 150 mg was compared with placebo in patients who had received at least three prior therapies, including imatinib. One-third of patients had received 4-7 prior therapies. Patients in the control arm had the option to receive therapy with ripretinib via crossover if progression was documented. Ripretinib had a significantly better median progression-free survival of 6.1 months than placebo (1.0 months). In addition, patients in the ripretinib arm had significantly better median overall survival (hazard ratio: 0.36). One-third of patients in the control arm were unable to crossover due to worsening general condition or death [68].
The standard dosage is 150 mg daily without interruption. Dose reduction, if indicated, is done in 50 mg steps.
6.2.4.6Therapy after failure of imatinib/sunitinib/regorafenib/ripretinib
If no study options are available in this situation, kinase inhibitor therapy should be continued to avoid tumor 'flare' after kinase inhibition is discontinued. The rapid deterioration of patients in the placebo arm of the INVICTUS trial dramatically underscored the risk of life-threatening flare. There is no robust evidence for effective therapeutic alternatives for treatment after ripretinib failure.
Conceptually, imatinib resistance develops clonally - so that usually, when initial resistance occurs, imatinib-sensitive metastases are still present alongside resistant clones. This also explains that, particularly in earlier lines of therapy, continuation or rechallenge with imatinib can partially control the disease [50, 51]. Imatinib is ineffective in cells harboring secondary mutations of KIT. In a 5th-line situation, one must assume complete imatinib resistance, and repeat imatinib therapy has no relevant prospect of efficacy. Preclinical studies show that sunitinib is active against mutations in the ATP-binding domain as well as against the gatekeeper mutation (T670I), whereas regorafenib, but especially ripretinib, show very broad efficacy against exon 17 and exon 18 mutations. For patients who do not experience general progression with ripretinib, the first option is to continue ("beyond progression") ripretinib or even rechallenge with sunitinib. This preserves the chance to control still responding metastases. Here, local therapies should also be evaluated, if necessary, to treat focal progression. Efficacy data for other TKIs, such as pazopanib, must be evaluated in the temporal context of their publication [52], as studies were conducted in much earlier lines of therapy. Preclinically, there is no evidence that pazopanib covers an additional spectrum of mutations compared with sunitinib and ripretinib. Based on evidence of KIT-independent resistance mechanisms, such as mutations that activate the PI3K pathway, some centers are using combinations with mTOR inhibitors. Imatinib combinations are not useful in this context due to the presence of imatinib resistance; however, there are safety data for combinations of sunitinib and sorafenib with, for example, sirolimus [69].
6.2.5Locoregional procedures for uni-/oligolocular progression
In case of uni- or oligolocular progression especially in symptomatic GIST, additional locoregional treatment procedures may be considered. Surgical resection, radiofrequency ablation (RFA), transarterial embolization (TAE) and/or selective internal radiation therapy (SIRT) may be considered as debatable therapeutic procedures. If tumor tissue is obtained in this context, another mutation analysis may be considered for further targeted drug treatment. The selection of suitable patients can only be done in a multidisciplinary approach.
6.2.6Substances
6.2.6.1Imatinib
Imatinib is a competitive inhibitor of ATP binding to the kinase domains of the KIT and PDGFRA receptors, leading to inhibition of signal transduction of these pathogenetically relevant tyrosine kinases. Imatinib is approved for the treatment of KIT-(CD 117)-positive unresectable and/or metastatic malignant gastrointestinal stromal tumors and for the adjuvant treatment of adults at significant risk of recurrence following resection of KIT-(CD 117)-positive GIST. The most commonly reported treatment-related adverse events (≥ 10%) are vomiting, diarrhea, abdominal pain, fatigue, myalgia, muscle cramps, skin redness, and edema. These should be treated consistently to maintain long-term compliance. Hematologic adverse events (neutropenia 10%, thrombocytopenia 1%, anemia 6%) occur less frequently than in patients with CML. Gastrointestinal bleeding occurs in up to 5% of patients during treatment.
6.2.6.2Sunitinib
Sunitinib is an inhibitor of the tyrosine kinases KIT, PDGFR-A and -B, VEGFR1-3, FLT3, and RET and is approved for the treatment of unresectable and/or metastatic GIST following treatment with imatinib.
The most common side effects are loss of appetite, impaired sense of taste, hypertension, fatigue, gastrointestinal complaints (e.g., diarrhea, nausea, stomatitis), and the occurrence of hand-foot syndrome. Endocrine (hypothyroidism), hematologic, or cardiac side effects may occur in patients treated long-term with multikinase inhibitors.
6.2.6.3Regorafenib
Regorafenib is an inhibitor of the tyrosine kinases VEGFR1-3, KIT, RET, TEK, RAF1, BRAF, PDGFRA and B, and FGFR and is approved as a third-line therapy for advanced GIST after failure of imatinib and sunitinib. Common side effects in CTCAE grade 3/4 include fatigue, diarrhea, hand-foot syndrome, and hypertension. Side effects occur after a median of 14 days and therefore require close monitoring (e.g., weekly) at the start of therapy and consistent dose reduction if necessary. The occurrence of changes in liver function tests (ALT, AST, bilirubin) are common, severe liver dysfunction is rare.
6.2.6.4Ripretinib
Ripretinib is a potent inhibitor of the tyrosine kinases KIT, PDGFRA, TIE2 as well as VEGFR2 and the serine/threonine kinase BRAF. Ripretinib binds in the posterior portion of the ATP binding pocket (back pocket) and exhibits high potency, particularly against secondary KIT mutations in the activation loop (exon 17 and 18). Ripretinib is approved for the treatment of patients with GIST who have received prior treatment with three or more kinase inhibitors, including imatinib. The most common (>2%) higher-grade (grade 3-4 by CTCAE) adverse events include anemia (7%), fatigue (2%), diarrhea (2%), loss of appetite (2%), dehydration (2%), hyperkalemia (2%), acute renal failure (2%), and pulmonary edema (2%). More common mild adverse events included alopecia (49%), myalgias (27%), nausea (25%), fatigue (24%), and hand-foot syndrome (21%). In contrast to sunitinib and regorafenib, arterial hypertension is rarely observed (5%).
6.2.6.5Avapritinib
Avapritinib is a highly potent type I PDGFRA inhibitor. Avapritinib is overall well tolerated with predominantly mild side effects (mild nausea, fatigue and periorbital edema). However, patients must be monitored with special vigilance for neurocognitive side effects, which can occur in more than 50% of cases, particularly in elderly patients. When explaining these side effects, people from the immediate social environment should always be included in order to sensitize them to the complex symptoms (impaired memory, movement disorders, psychiatric symptoms, behavioral changes, etc.).
7[Chapter not relevant]
8Follow-up/Control examinations
After complete tumor resection, clinical controls including CT abdomen/pelvis - depending on the risk - should be performed every 3-6 months during the first 5 years, then once a year. For small tumors (<2 cm), longer intervals may be selected if necessary. MRI examinations may also be performed after a longer recurrence-free period and when the risk of recurrence is low to reduce abdominal radiation exposure. Abdominal ultrasonography is not recommended because the sensitivity for peritoneal metastases is too low. Regular endoscopic follow-up is currently no longer recommended because the local recurrence rate after complete resection is very low.
For follow-up of existing metastases, intervals of about 3-4 months are usually chosen. Here, too, CT abdomen/pelvis examinations are the method of choice, especially for the detection of peritoneal metastases and for the follow-up of hepatic metastases also by means of density measurement [22].
9References
Joensuu H, Hohenberger P, Corless CL: Gastrointestinal stromal tumour. Lancet. Sep 14, 2013;382(9896):973-983. DOI:10.1016/S0140-6736(13)60106-3
Special evaluation of the Society of Epidemiological Cancer Registries in Germany (GEKID). For methodology, see GEKID Atlas: Gesellschaft der epidemiologischen Krebsregister in Deutschland e.V. Atlas der Krebsinzidenz und -mortalität in Deutschland (GEKID Atlas). Lübeck, 2017. Available from: http://www.gekid.de. Case definition: ICD-O3: morphology codes 8936/1 and 8936/9. Countries in the pool: SH, NI, HB, RegBez Münster, BY, BB, MV, SN, TH.
Ressing M, Wardelmann E, Hohenberger P, et al: Strengthening health data on a rare and heterogeneous disease: sarcoma incidence and histological subtypes in Germany. BMC Public Health. February 12, 2018;18(1):235. DOI:10.1186/s12889-018-5131-4
Mazzola P, Spitale A, Banfi S et al: Epidemiology and molecular biology of gastrointestinal stromal tumors (GISTs): a population-based study in the South of Switzerland, 1999-2005. Histol Histopathol. November 2008;23(11):1379-1386. DOI:10.14670/HH-23.1379
Ducimetière F, Lurkin A, Ranchère-Vince D et al: Incidence of sarcoma histotypes and molecular subtypes in a prospective epidemiological study with central pathology review and molecular testing. PLoS ONE. 2011;6(8):e20294. DOI:10.1371/journal.pone.0020294
Tumor Registry Munich. Survival GIST: Gastrointestinal Stromal tumor [Internet]. 2018 [updated Aug 22 2018]. Retrieved from: https://www.tumorregister-muenchen.de/facts/surv/shgistg-gist-gastroint.-stromatumor-survival
Søreide K, Sandvik OM, Søreide JA et al: Global epidemiology of gastrointestinal stromal tumours (GIST): A systematic review of population-based cohort studies. Cancer Epidemiol. February 2016;40:39-46. DOI:10.1016/j.canep.2015.10.031
Tran T, Davila JA, El-Serag HB: The epidemiology of malignant gastrointestinal stromal tumors: an analysis of 1,458 cases from 1992 to 2000. Am J Gastroenterol. January 2005;100(1):162-168. PMID:15654796
Quek R, George S: Gastrointestinal stromal tumor: a clinical overview. Hematol Oncol Clin North Am. February 2009;23(1):69-78, viii. DOI:10.1016/j.hoc.2008.11.006
Schildhaus H-U, Merkelbach-Bruse S, Büttner R et al: Pathology and molecular biology of gastrointestinal stromal tumors (GIST). The Radiologist. Dezember 2009;49(12):1104-1108. https://link.springer.com/article/10.1007/s00117-009-1850-y
Huss S, Künstlinger H, Wardelmann E et al: A subset of gastrointestinal stromal tumors previously regarded as wild-type tumors carries somatic activating mutations in KIT exon 8 (p.D419del). Mod Pathol. Juli 2013;26(7):1004-1012. https://www.nature.com/articles/modpathol201347
Huss S, Pasternack H, Ihle MA et al: Clinicopathological and molecular features of a large cohort of gastrointestinal stromal tumors (GISTs) and review of the literature: BRAF mutations in KIT/PDGFRA wild-type GISTs are rare events. Hum Pathol. April 2017;62:206-214. DOI:10.1016/j.humpath.2017.01.005
Agarwal R, Robson M: Inherited predisposition to gastrointestinal stromal tumor. Hematol Oncol Clin North Am. February 2009;23(1):1-13, vii. DOI:10.1016/j.hoc.2008.12.003
Mucciarini C, Rossi G, Bertolini F et al: Incidence and clinicopathologic features of gastrointestinal stromal tumors. A population-based study. BMC Cancer. December 20, 2007;7:230. DOI:10.1186/1471-2407-7-230
Agaimy A, Dirnhofer S, Wünsch PH et al: Multiple sporadic gastrointestinal stromal tumors (GISTs) of the proximal stomach are caused by different somatic KIT mutations suggesting a field effect. Am J Surg Pathol. Oktober 2008;32(10):1553-1559. DOI:10.1097/PAS.0b013e31817587ea
Agaimy A, Wünsch PH, Hofstaedter F et al: Minute gastric sclerosing stromal tumors (GIST tumorlets) are common in adults and frequently show c-KIT mutations. Am J Surg Pathol. January 2007;31(1):113-120. DOI:10.1097/01.pas.0000213307.05811.f0
Kawanowa K, Sakuma Y, Sakurai S et al: High incidence of microscopic gastrointestinal stromal tumors in the stomach. Hum Pathol. Dezember 2006;37(12):1527-1535. DOI:10.1016/j.humpath.2006.07.002
Choi H, Charnsangavej C, Faria SC et al: Correlation of computed tomography and positron emission tomography in patients with metastatic gastrointestinal stromal tumor treated at a single institution with imatinib mesylate: proposal of new computed tomography response criteria. J Clin Oncol. 1 May 2007;25(13):1753-1759. DOI:10.1200/JCO.2006.07.3049
Chaudhry UI, DeMatteo RP: Management of resectable gastrointestinal stromal tumor. Hematol Oncol Clin North Am. February 2009;23(1):79-96, viii. DOI:10.1016/j.hoc.2009.01.001
Eriksson M, Reichardt P, Sundby Hall K et al: Needle biopsy through the abdominal wall for the diagnosis of gastrointestinal stromal tumour - Does it increase the risk for tumour cell seeding and recurrence? Eur J Cancer. May 2016;59:128-133. DOI:10.1016/j.ejca.2016.02.021
Langer C, Schüler P, Becker H, Liersch T: [Gastrointestinal stromal tumors from the surgical point of view. Laparoscopic therapy]. Surgeon. July 2008;79(7):644-649. DOI:10.1007/s00104-008-1528-4
Casali PG, Blay JY, Abecassis N et al: Gastrointestinal stromal tumours: ESMO-EURACAN-GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. January 2022;33(1):20-33. DOI:10.1016/j.annonc.2021.09.005
Wittekind C. TNM: classification of malignant tumors. 8th edition ed. Wiley VCH Verlag GmbH; 2017. https://www.wiley-vch.de/de/fachgebiete/medizin-und-gesundheit/tnm-klassifikation-maligner-tumoren-978-3-527-34280-8
Joensuu H, Vehtari A, Riihimäki J et al: Risk of recurrence of gastrointestinal stromal tumour after surgery: an analysis of pooled population-based cohorts. Lancet Oncol. March 2012;13(3):265-274. DOI:10.1016/S1470-2045(11)70299-6
Miettinen M, Lasota J: Gastrointestinal stromal tumors: pathology and prognosis at different sites. Semin Diagn Pathol. May 2006;23(2):70-83. DOI:10.1053/j.semdp.2006.09.001
Lasota J, Miettinen M: KIT and PDGFRA mutations in gastrointestinal stromal tumors (GISTs). Semin Diagn Pathol. May 2006;23(2):91-102. DOI:10.1053/j.semdp.2006.08.006
Hohenberger P, Ronellenfitsch U, Oladeji O et al: Pattern of recurrence in patients with ruptured primary gastrointestinal stromal tumour. Br J Surg. dec 2010;97(12):1854-1859. DOI:10.1002/bjs.7222
Eisenberg BL, Harris J, Blanke CD et al: Phase II trial of neoadjuvant/adjuvant imatinib mesylate (IM) for advanced primary and metastatic/recurrent operable gastrointestinal stromal tumor (GIST): early results of RTOG 0132/ACRIN 6665. J Surg Oncol. January 1, 2009;99(1):42-47. DOI:10.1002/jso.21160
Bauer S, Rutkowski P, Hohenberger P et al: Long-term follow-up of patients with GIST undergoing metastasectomy in the era of imatinib -- analysis of prognostic factors (EORTC-STBSG collaborative study). Eur J Surg Oncol. April 2014;40(4):412-419. DOI:10.1016/j.ejso.2013.12.020
Bauer S, Hartmann JT, de Wit M et al: Resection of residual disease in patients with metastatic gastrointestinal stromal tumors responding to treatment with imatinib. Int J Cancer. Nov. 1, 2005;117(2):316-325. DOI:10.1002/ijc.21164
Gronchi A, Fiore M, Miselli F et al: Surgery of residual disease following molecular-targeted therapy with imatinib mesylate in advanced/metastatic GIST. Ann Surg. march 2007;245(3):341-346. DOI:10.1097/01.sla.0000242710.36384.1b
Raut CP, Posner M, Desai J et al: Surgical management of advanced gastrointestinal stromal tumors after treatment with targeted systemic therapy using kinase inhibitors. J Clin Oncol. 20 May 2006;24(15):2325-2331. DOI:10.1200/JCO.2005.05.3439
DeMatteo RP, Ballman KV, Antonescu CR et al: Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial. Lancet. March 28, 2009;373(9669):1097-1104. DOI:10.1016/S0140-6736(09)60500-6
Joensuu H, Eriksson M, Sundby-Hall K, et al: Survival outcomes associated with 3 years vs 1 year of adjuvant imatinib for patients with high-risk gastrointestinal stromal tumors. An analysis of a randomized clinical trial after 10-year follow-up. JAMA Oncol. 1 Aug 2020; 6:1241-1246. DOI:10.1001/jamaoncol.2020.2091
Casali PG, Le Cesne A, Poveda Velasco A et al: Time to definitive failure to the first tyrosine kinase inhibitor in localized GI stromal tumors treated with imatinib as an adjuvant: A European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group Intergroup randomized trial in collaboration with the Australasian Gastro-Intestinal Trials Group, UNICANCER, French Sarcoma Group, Italian Sarcoma Group, and Spanish Group for Research on Sarcomas. J Clin Oncol. dec 20, 2015;33(36):4276-4283. DOI:10.1200/JCO.2015.62.4304
Verweij J, Casali PG, Zalcberg J et al: Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: randomised trial. Lancet. Oct. 25, 2004;364(9440):1127-1134. DOI:10.1016/S0140-6736(04)17098-0
Blanke CD, Rankin C, Demetri GD et al: Phase III randomized, intergroup trial assessing imatinib mesylate at two dose levels in patients with unresectable or metastatic gastrointestinal stromal tumors expressing the kit receptor tyrosine kinase: S0033. J Clin Oncol. 1 Feb 2008;26(4):626-632. DOI:10.1200/JCO.2007.13.4452
Gastrointestinal Stromal Tumor Meta-Analysis Group (MetaGIST): Comparison of two doses of imatinib for the treatment of unresectable or metastatic gastrointestinal stromal tumors: a meta-analysis of 1,640 patients. J Clin Oncol. march 1, 2010;28(7):1247-1253. DOI:10.1200/JCO.2009.24.2099
Heinrich MC, Rankin C, Blanke CD et al: Correlation of long-term results of imatinib in advanced gastrointestinal stromal tumors with next-generation sequencing results: analysis of phase 3 SWOG Intergroup trial S0033. JAMA Oncol. july 1, 2017;3(7):944-952. DOI:10.1001/jamaoncol.2016.6728
Heinrich MC, Corless CL, Demetri GD et al: Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor. J Clin Oncol. dec 1, 2003;21(23):4342-4349. DOI:10.1200/JCO.2003.04.190
Heinrich MC, Owzar K, Corless CL et al: Correlation of kinase genotype and clinical outcome in the North American Intergroup Phase III Trial of imatinib mesylate for treatment of advanced gastrointestinal stromal tumor: CALGB 150105 Study by Cancer and Leukemia Group B and Southwest Oncology Group. J Clin Oncol. nov 20, 2008;26(33):5360-5367. DOI:10.1200/JCO.2008.17.4284
Le Cesne A, Ray-Coquard I, Bui BN et al: Discontinuation of imatinib in patients with advanced gastrointestinal stromal tumours after 3 years of treatment: an open-label multicentre randomised phase 3 trial. Lancet Oncol. Oktober 2010;11(10):942-949. DOI:10.1016/S1470-2045(10)70222-9
Gramza AW, Corless CL, Heinrich MC: Resistance to tyrosine kinase inhibitors in gastrointestinal stromal tumors. Clin Cancer Res. Dec. 15, 2009;15(24):7510-7518. DOI:10.1158/1078-0432.CCR-09-0190
Gronchi A, Blay J-Y, Trent JC: The role of high-dose imatinib in the management of patients with gastrointestinal stromal tumor. Cancer. April 15, 2010;116(8):1847-1858. DOI:10.1002/cncr.24944
Davio K: Avapritinib could deliver precision medicine to patients with GIST, says Heinrich. 2018 CTOS Annual Meeting. https://www.targetedonc.com/conference/ctos-2018/avapritinib-could-deliver-precision-medicine-to-patients-with-gist-says-heinrich
Demetri GD, van Oosterom AT, Garrett CR et al: Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial. Lancet. Oct 14, 2006;368(9544):1329-1938. DOI:10.1016/S0140-6736(06)69446-4
George S, Blay JY, Casali PG et al: Clinical evaluation of continuous daily dosing of sunitinib malate in patients with advanced gastrointestinal stromal tumour after imatinib failure. Eur J Cancer. July 2009;45(11):1959-1968. DOI:10.1016/j.ejca.2009.02.011
Reichardt P, Kang Y-K, Rutkowski P et al: Clinical outcomes of patients with advanced gastrointestinal stromal tumors: safety and efficacy in a worldwide treatment-use trial of sunitinib. Cancer. May 1, 2015;121(9):1405-1413. DOI:10.1002/cncr.29220
Demetri GD, Reichardt P, Kang Y-K et al: Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet. Jan. 26, 2013;381(9863):295-302. DOI:10.1016/S0140-6736(12)61857-1
Italiano A, Cioffi A, Coco P et al: Patterns of care, prognosis, and survival in patients with metastatic gastrointestinal stromal tumors (GIST) refractory to first-line imatinib and second-line sunitinib. Ann Surg Oncol. May 2012;19(5):1551-1559. DOI:10.1245/s10434-011-2120-6
Kang Y-K, Ryu M-H, Yoo C et al: Resumption of imatinib to control metastatic or unresectable gastrointestinal stromal tumours after failure of imatinib and sunitinib (RIGHT): a randomised, placebo-controlled, phase 3 trial. Lancet Oncol. November 2013;14(12):1175-1182. DOI:10.1016/S1470-2045(13)70453-4
Mir O, Cropet C, Toulmonde M et al: Pazopanib plus best supportive care versus best supportive care alone in advanced gastrointestinal stromal tumours resistant to imatinib and sunitinib (PAZOGIST): a randomised, multicentre, open-label phase 2 trial. Lancet Oncol. May 2016;17(5):632-641. DOI:10.1016/S1470-2045(16)00075-9
Verschoor AJ, Bovée JVMG, Overbeek LIH; PALGA group, Hogendoorn PCW, Gelderblom H. The incidence, mutational status, risk classification and referral pattern of gastro-intestinal stromal tumours in the Netherlands: a nationwide pathology registry (PALGA) study. Virchows Arch. February 2018;472(2):221-229. DOI:10.1007/s00428-017-2285-x
Netherlands Cancer Registry (NCR), Netherlands Comprehensive Cancer Organisation (IKNL), derived via www.iknl.nl/en/ncr/ncr-data-figures [01/06/2022].
Menge F, Jakob J, Kasper B, Smakic A, Gaiser T, Hohenberger P. Clinical presentation of gastrointestinal stromal tumors. Visc Med Oct 2018;34(5):335-340. DOI:10.1159/000494303
Mohammadi M, IJzerman NS, Hohenberger P et al: Clinicopathological features and treatment outcome of oesophageal gastrointestinal stromal tumor (GIST): A large, retrospective multicenter European study. Eur J Surg Oncol. August 2021;47(8):2173-2181. DOI:10.1016/j.ejso.2021.03.234
Vassos N, Jakob J, Kähler G et al: Preservation of organ function in locally advanced non-metastatic gastrointestinal stromal tumors (GIST) of the stomach by neoadjuvant imatinib therapy. Cancers (Basel). February 3, 2021;13(4):586. DOI:10.3390/cancers13040586
Corless CL, Schroeder A, Griffith D et al: PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib. J Clin Oncol. aug 10, 2005;23(23):5357-5364. DOI:10.1200/JCO.2005.14.068
Gastrointestinal Stromal Tumor Meta-Analysis Group (MetaGIST). Comparison of two doses of imatinib for the treatment of unresectable or metastatic gastrointestinal stromal tumors: a meta-analysis of 1,640 patients. J Clin Oncol. march 1, 2010;28(7):1247-1253. DOI:10.1200/JCO.2009.24.2099
Mühlenberg T, Ketzer J, Heinrich MC et al: KIT-dependent and KIT-independent genomic heterogeneity of resistance in gastrointestinal stromal tumors - TORC1/2 inhibition as salvage strategy. Mol Cancer Ther. November 2019;18(11):1985-1996. DOI:10.1158/1535-7163.MCT-18-1224
Serrano C, Fletcher JA: Overcoming heterogeneity in imatinib-resistant gastrointestinal stromal tumor. Oncotarget. Oct 29, 2019;10(59):6286-6287. DOI:10.18632/oncotarget.27277
Jilg S, Rassner M, Maier J et al: Circulating cKIT and PDGFRA DNA indicates disease activity in Gastrointestinal Stromal Tumor (GIST). Int J Cancer. Oct 15, 2019;145(8):2292-2303. DOI:10.1002/ijc.32282
Gómez-Peregrina D, García-Valverde A, Pilco-Janeta D, Serrano C: Liquid biopsy in gastrointestinal stromal tumors: ready for prime time? Curr Treat Options Oncol. 27 Feb 2021;22(4):32. DOI:10.1007/s11864-021-00832-5
Jones RL, Serrano C, von Mehren M et al: Avapritinib in unresectable or metastatic PDGFRA D842V-mutant gastrointestinal stromal tumours: long-term efficacy and safety data from the NAVIGATOR phase I trial. Eur J Cancer. Mar 2021;145:132-142. DOI:10.1016/j.ejca.2020.12.008
Heinrich MC, Jones RL, von Mehren M et al: Avapritinib in advanced PDGFRA D842V-mutant gastrointestinal stromal tumour (NAVIGATOR): a multicentre, open-label, phase 1 trial. Lancet Oncol. July 2020;21(7):935-946. DOI:10.1016/S1470-2045(20)30269-2
Joseph CP, Abaricia SN, Angelis MA et al: Optimal avapritinib treatment strategies for patients with metastatic or unresectable gastrointestinal stromal tumors. Oncologist. April 2021;26(4):e622-e631. DOI:10.1002/onco.13632
Grunewald S, Klug LR, Mühlenberg T et al: Resistance to avapritinib in PDGFRA-driven GIST is caused by secondary mutations in the PDGFRA kinase domain. Cancer Discov. Jan 2021;11(1):108-125. DOI:10.1158/2159-8290.CD-20-0487
Blay JY, Serrano C, Heinrich MC et al: Ripretinib in patients with advanced gastrointestinal stromal tumours (INVICTUS): a double-blind, randomised, placebo-controlled, phase 3 trial. Lancet Oncol. July 2020;21(7):923-934. DOI:10.1016/S1470-2045(20)30168-6
Gangadhar TC, Cohen EE, Wu K et al: Two drug interaction studies of sirolimus in combination with sorafenib or sunitinib in patients with advanced malignancies. Clin Cancer Res. April 1, 2011;17(7):1956-1963. DOI:10.1158/1078-0432.CCR-10-2061
Nishida T, Holmebakk T, Raut CP, Rutkowski P. Defining tumor rupture in gastrointestinal stromal tumor. Ann Surg Oncol. 2019;26(6):1669–1675.
Lu J, Dai Y, Zheng HL et al. What is the appropriate duration of adjuvant imatinib mesylate treatment for primary gastrointestinal stromal tumors classified according to the strict definition of tumor rupture? Medicine (Baltimore). 2019;98(3):e14177.
Nishida T, Sato S, Ozaka M, Nakahara Y, Komatsu Y, Kondo M, et al. Long-term adjuvant therapy for high-risk gastrointestinal stromal tumors in the real world. Gastric Cancer. 2022;25(5):956–965.
Bang YH, Ryu MH, Kim HD, Lee HE, Kang YK. Clinical outcomes and prognostic factors for patients with high-risk gastrointestinal stromal tumors treated with 3-year adjuvant imatinib. Int J Cancer. 2022;151(10):1770–1777.
Gotohda N, Nishida T, Sato S et al. Re-appraisal of the universal definition of tumor rupture among patients with high-risk gastrointestinal stromal tumors. Ann Gastroenterol Surg. 2023 Apr 26;7(6):1021-1031.
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15Authors' Affiliations
Innere Klinik (Tumorforschung)
Westdeutsches Tumorzentrum
Onko-Zentrum
Chirurgische Klinik
Robert Koch-Institut
Krebsregister Schleswig-Holstein
Klinik für Interdisziplinäre Onkologie
Sarkomzentrum Berlin-Brandenburg
Gerhard-Domagk-Institut für Pathologie
16Disclosure of Potential Conflicts of Interest
| Author | Employer1 | Consulting / Expert opinion2 | Shares / Funds3 | Patent / Copyright / License 4 | Fees5 | Funding of scientific research6 | Other financial relations7 | Personal relationship with authorized representatives8 |
|---|---|---|---|---|---|---|---|---|
| Bauer, Sebastian |
Universitätsklinikum Essen
|
Yes
Blueprint Medicines, Deciphera, IDRX, Cogent, Adcendo, Boehringer Ingelheim
|
No
|
Yes
Co-Inventor (KIT-Inhibitor); Patent submitted by University, patent not granted yet.
|
Yes
Pfizer, Deciphera, Blueprint Medicines
|
Yes
IDRX (institutional)
von Pfeffel (institutional)
|
No
|
No
|
| Dürr, Donat |
Zuger Kantonsspital
Landhausstrasse 11
6340 Baar
|
No
|
Yes
Aktien von Roche und Novartis
|
No
|
No
|
No
|
No
|
No
|
| Hohenberger, Peter |
Univeristätsklinikum Mannheim
|
Yes
Boehringer Ingelheim
Lighthouse PTC
Deciphera
Blueprint Medicines
|
No
|
No
|
Yes
PharmaMar
Deciphera
Blueprint Medicines
Asklepios
|
No
|
No
|
No
|
| Kraywinkel, Klaus |
Robert Koch-Institut, Berlin
|
No
|
No
|
No
|
No
|
No
|
No
|
No
|
| Pritzkuleit, Ron |
Institut für Krebsepidemiologie an der Universität Lübeck
Registerstelle des Krebsregisters Schleswig-Holstein
Ratzeburger Allee 160
23538 Lübeck
|
No
|
No
|
No
|
No
|
No
|
No
|
No
|
| Reichardt, Peter |
Helios Klinikum Berlin-Buch GmbH
|
Yes
Bayer, Novartis, Deciphera, PharmaMar, GSK, Boehringer Ingelheim
|
No
|
No
|
Yes
Deciphera, PharmaMar, Boehringer Ingelheim
|
No
|
No
|
No
|
| Wardelmann, Eva |
Universitätsklinikum Münster
Gerhard-Domagk-Institut für Pathologie
|
Yes
Bayer Advisory Board
Roche Advisory Board
Boehringer Ingelheim Pharma GmbH & Co. KG Advisory Board
Novartis Precision Oncology Advisory Board
Bristol Myers Squipp
PharmaMar Advisory Board
Sanofi Advisory Board
|
No
|
No
|
Yes
Asklepios
Bristol Myers Squibb
|
Yes
Institut für Klinische Krebsforschung am Krankenhaus Nordwest - NITRASARC Studie
PharmaMar - E-TRAB-Studie
|
Yes
Honorare von QuiP für die Durchführung von immunhistochemischen Ringversuchen
|
No
|
2 - Activity as a consultant or expert or paid participation in a scientific advisory board of a company in the health care industry (e.g., pharmaceutical industry, medical device industry), a commercially oriented contract research organization, or an insurance company.
3 - Ownership of business shares, stocks, funds with participation of companies of the health care industry.
4 - Relates to drugs and medical devices.
5 - Honoraria for lecturing and training activities or paid authors or co-authorships on behalf of a company in the health care industry, a commercially oriented contracting institute or an insurance company.
6 - Financial support (third-party funds) for research projects or direct financing of employees of the institution by a company in the health care industry, a commercially oriented contract institute or an insurance company.
7 - Other financial relationships, e.g., gifts, travel reimbursements, or other payments in excess of 100 euros outside of research projects, if paid by an entity that has an investment in, license to, or other commercial interest in the subject matter of the investigation.
8 - Personal relationship with an authorized representative(s) of a healthcare company.
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